Port 4501 is GlobalProtect IPSec, UDP.
UDP
low risk
App-IDglobalprotect
Palo Alto GlobalProtect — IPSec/ESP tunnel port. Preferred over SSL tunnel for better throughput.
Palo Alto
Create the service object for this port, then allow the App-ID on it. Restricting the rule to the port's service object keeps the rule working on a non-default port and stops the App-ID matching on other ports. Replace the placeholders with your own rule name and zones.
set service udp-4501 protocol udp port 4501
set rulebase security rules <rule-name> from <from-zone> to <to-zone> source any destination any application globalprotect service udp-4501 action allow
Risk and exposure
Rated low risk. Even so, only expose this port to the networks and hosts that need it, and keep it patched.
Check it
- Linux
ss -ulnp | grep :4501 - nmap
nmap -sU -p 4501 <host>